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Diabetes causes atherosclerosis ] the real cause of diabetes although there are many exceptions major goal is keeping the daytime amounts levels between 80. Causes cholesterol is high cholesterol can cause atherosclerosis, a dangerous accumulation of cholesterol and other deposits on the walls of your arteries. Atherosclerosis is a narrowing of the arteries caused by a buildup of plaque it’s also called arteriosclerosis or hardening of the arteries, and it can lead to.